The town got its name from Am­fissa who, ac­cord­ing to myth, was a mis­tress of the god Apollo and the daugh­ter of Macar, a son of Ae­o­lus.

In 338 B.C., Amfissa was destroyed by Philip II of Macedonia who had been called upon by the Amphictyonic League during the Third Sacred War. He demolished the city and wrecked its acropolis as punishment because the Amfissians had cultivated land on the Crissaean plain, which belonged to Delphi and the Amphictyonic League.

During the 13th century A.D., the city was known as Salona. Its name most likely came from the Frank family de Chalons, members of which ruled the area.

(source & copyright: learn more at theDelphiGuide.com)